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KMID : 0854720000200060895
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Korean Journal of Asthma, Allergy and Clinical Immunology
2000 Volume.20 No. 6 p.895 ~ p.905
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Relationship of eosinophils in induced sputum with bronchial responsiveness to methacholine or capsaicin and with responses to anti-asthmatic treatment in chronic cough patients
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Lee Byung-Jae
Chung Jae-Won
Chang Yoon-Seok
Chang Yoon-Hae
Kim Sang-Hoon
Chung Hee
Kim Yoon-Keun
Cho Sang-Heon
Min Kyung-Up
Kim You-Young
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Abstract
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Background : The value of the induced sputum examination in chronic cough has not been determined. We performed this study to investigate the relationship between eosinophil percentage on induced sputum and bronchial responsiveness to methacholine or capsaicin, and responses to anti-asthmatic treatment in chronic cough patients.
Subjects and Methods : Forty-seven patients with chronic cough persisting for more than 1 month without current wheezing or dyspnea were studied. According to the eosinophil percentage on induced sputum, the subjects were divided into two groups: group A (sputum eosinophil 3%) and group B (sputum eosinophil < 3%). Methacholine bronchial provocation test (MBPT) and capsaicin challenge, and responses to anti-asthmatic treatment were compared between the two groups.
Results : Group A consisted of 26 subjects and group B consisted of 21 subjects. There were no differences in sex, clinical characteristics of cough. atopy prevalence, and peripheral eosinophil counts except serum IgE level between the two groups. MBPT positivity was much higher in group A than group B (46.2% vs 0%, p<0.001). but there was no difference in capsaicin test pcsitivity(44.0% vs 50.0%). Group A showed much higher response rates to anti-asthmatic treatments than in group B (73.1% vs 19.0%. p<0.001).
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KEYWORD
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Induced sputum, eosinophil, chronic cough, methacholine, capsaicin, asthma,
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